Publications

Publications

Hybrid Nanostructures (HNS)
A Single Slow Electron Triggers the Loss of Both
A Single Slow Electron Triggers the Loss of Both Chlorine Atoms from the Anticancer Drug Cisplatin: Implications for Chemoradiation Therapy
2009
J. Kopyra, C. Koenig-Lehmann, I. Bald, E. Illenberger
Leaner, meaner cisplatin: Dissociative electron attachment to the anticancer drug cisplatin (1) shows intense resonances at very low energies, which result in Pt*Cl bond cleavage. A single low‐energy electron can trigger the loss of both chlorine atoms from cisplatin (see scheme), thereby forming [Pt(NH3)2]−. This complex is the reactive intermediate to form cisplatin–DNA adducts, which consequently inhibit DNA replication.
Journal Article

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